Web13 nov. 2024 · Lysosomal proteins, such as cathepsins, can play a role in both tumorigenesis and cancer cell apoptosis. ... Huang H-Y, Lin M-T, Chang K-J, Kuo M-L (2009) Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer research 69(8):3482–3491. CAS … A lysosome is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis, analogous to the activity of the stomach. Besi…
A polylysine–polyhistidine fusion peptide for lysosome …
Web22 dec. 2024 · Lysosomes are membrane-bound acidic cellular organelles containing hydrolytic enzymes that degrade various biomacromolecules such as carbohydrates, … Web26 feb. 2024 · ABCB1 lysosomes lysosomal membrane permeabilization lysosomal P-gp activity P-gp P-gp endocytosis redox-active (-cycling) thiosemicarbazone complexes thiosemicarbazone thiosemicarbazone ionization Figures References Related Details Cited By Structural feature-driven pattern analysis for multitarget modulator landscapes hanns scharff book
Endosomes, lysosomes, and the role of endosomal and lysosomal ...
Web9 iul. 2024 · Notably, the lysosome recently emerged as promising target to overcome chemoresistance, as increasing evidence suggests that it is involved in P-gp trafficking, … Web1 sept. 1975 · Review Article Lysosomes And The Skin Gerald S. Lazarus, 1 2 Victor B. Hatcher, 3 Norman Levine, 4 1 Department of Medicine, Albert Einstein College of Medicine Department of Medicine, Albert Einstein College of Medicine 2 Senior Investigator, Arthritis Foundation U.S.A. Senior Investigator, Arthritis Foundation U.S.A. 3 … Web20 iun. 2024 · Lysosomes have been shown to trap certain hydrophobic weak base chemotherapeutics, as well as some tyrosine kinase inhibitors, thereby being sequestered away from their intracellular target site. Lysosomal sequestration is in most cases followed by the release of their content from the cell by exocytosis. ch 9 geography