Web22 mar. 2024 · Article highlights. Methotrexate is an appropriate medication for the treatment of various malignancies and immune-mediated diseases. Several studies have … Web25 mai 2024 · e19204 Background: Methotrexate (MTX) is used in high doses for the treatment of ALL, lymphoma, and metastatic breast cancer with CNS involvement. To …
Risk factors for high-dose methotrexate-induced nephrotoxicity
Web3 aug. 2024 · for MTX toxicity. When MTX levels remain elevated despite urinary alkalinization and the administration of leucovorin, glucarpidase can be added to the … Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, r… the seeds fumetto
Fatal low‐dose methotrexate toxicity: A case report ... - ResearchGate
Web1 nov. 2004 · BACKGROUND AND PURPOSE: Acute lymphocytic leukemia (ALL) is a common malignancy of childhood treated with methotrexate (MTX), which is associated … Web22 apr. 2024 · The use of low-dose MTX in patients with RA and other rheumatic diseases and the clinical use and adverse effects of high-dose MTX and related adverse effects … WebHigh Dose Methotrexate (HD-MTX) toxicity can cause renal dysfunction in patients due to a presence of risk factors such as body mass index >25 kg/m2, comedication, and Glucarpidase can be used which degrades MTX to its metabolites which may lead to further renal toxicity by precipitation in the renal tubules. the seed school of miami fl