2024 Otud6a topbp1

Otud6a topbp1

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August undefined, 2024

WebDeubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Authors - Yan Zhao. View … WebTOPBP1. DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. [5] [6] [7] TOPBP1 was first identified as a …

TOPBP1 - ATM Interaction Summary BioGRID

http://www.pepge.pku.edu.cn/Index/scientific/cid/12/id/2975.html WebWang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ, Cheng X, Li C, Yang R, Wang CC, Wu G, Lu QL, Bai Y, Huang YF, Yin D, Yang Q, Wang XJ ... peru national basketball team

High levels of TopBP1 induce ATR-dependent shut-down of rRNA ...

WebApr 1, 2024 · TopBP1 is an important protein for activating ATR following replication stress. ... Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 … http://www.pepge.pku.edu.cn/English/Index/scientific/cid/61/id/2976.html WebJul 14, 2024 · 进一步研究发现，敲低去泛素化酶otud6a ，能使细胞阻滞在s期，导致chk1激活受阻，并使得基因组不稳定性提高，进而增加肿瘤细胞对化疗药物的敏感性。裸鼠成瘤实验也表明，otud6a的敲低通过负调控topbp1蛋白水平，抑制了乳腺癌肿瘤的生长。 peru national football kit

Deubiquitinase OTUD6A Promotes Breast Cancer Progression

TopBP1 (D8G4L) Rabbit mAb Cell Signaling Technology

WebMar 21, 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel Syndrome.Among its related pathways are Homologous DNA Pairing and Strand Exchange and Homology Directed Repair.Gene Ontology (GO) annotations related to this gene … WebShowing of 852 Results for OTUD6A Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score; 1: ... TOPBP1: DNA Topoisomerase II Binding Protein 1: Protein Coding: Q92547: 48: GC03M133600: 1.64: 22: UBR5: Ubiquitin Protein Ligase E3 Component N-Recognin 5: Protein Coding: O95071: 47: stan southWebAug 15, 2024 · TOPBP1 and NBN had higher codependence with CIP2A in BLBC than in HGSOC cells, whereas in HGSOC, RHNO1 was more co-dependent with CIP2A . These differences may provide one plausible explanation for the differential requirement of Cip2a for DMBA-induced BLBC-like, but not ovarian cancer initiation (Fig. 1C; Supplementary Fig. … peru national food dish

"WebSep 9, 2024 · Cytokinin plays critical roles in root development. Cytokinin signaling depends on activation of key transcription factors known as type B Arabidopsis response … " - Otud6a topbp1

Otud6a topbp1

WebMay 18, 2010 · Function. Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as … WebSubsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase UBR5, decreasing …

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WebOTUD6A is upregulated in human patients with colorectal cancer. The depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission, and the affected cells are consequently less prone to tumorigenesis. Conversely, the overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth. WebMar 19, 2015 · Human TopBP1 plays essential roles in DNA replication and replication checkpoint control. In our recent paper “TopBP1 controls BLM protein level to maintain genome stability,” we provided evidence suggesting that TopBP1 has an unexpected role in suppressing sister chromatid exchange (SCE) and that this function is independent of its …

Web该研究发现otud6a通过调控topbp1蛋白的泛素化修饰和稳定性来参与dna损伤修复，维持细胞基因组稳定性，抑制肿瘤细胞对放化疗药物的敏感性并促进乳腺癌的发展。揭示了去泛素化酶otud6a参与dna损伤应答及调控肿瘤细胞耐药的分子机制。 WebFeb 25, 2024 · These results indicate that OTUD6A is a physiological DUB for c-Myc in PrCa setting and ... Deubiquitinase OTUD6A promotes breast cancer progression by increasing …

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WebApr 27, 2015 · Expression of ectopic TopBP1 induces shut-down of rRNA transcription and nucleolar segregation. (A) Expression of eGFP-TopBP1 was left non-induced (eGFP … peru nationality calledWebFeb 7, 2024 · Title: Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. … peru national holidaysWebDeubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy: Y. Zhao, et al.; Cell Death … stan south park voice actorWebOTUD6A is part of cluster 11 Basophils - Unknown function with confidence i 0.61 166 genes in cluster Go to interactive expression cluster page. 15 nearest neighbours based on … stan south park pngWebJun 30, 2024 · Deubiquitinase OTUD6A Promotes Breast Cancer Progression by Increasing TopBP1 Stability and Rendering Tumor Cells Resistant to DNA-Damaging Therapy. … stans paint rexburg idahoWebDeubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy peru nationality in englishWebMar 21, 2024 · OTUD6A (OTU Deubiquitinase 6A) is a Protein Coding gene. Diseases associated with OTUD6A include Junctional Epidermolysis Bullosa Non-Herlitz Type . … peru national holidays 2022